Inflammation Test

Description

Inflammation is a part of the body’s defense mechanism against infections and diseases. A healthy immune system is characterized by low levels of inflammation under normal circumstances, and elevated levels in case of injury, infection or trauma.
Inflammation can be of two types- acute (short term) and chronic (long term). Acute inflammation is the body’s immediate response to an injury or infection. It manifests quickly and disappears once the infection is cleared. Chronic Inflammation can be a result of unresolved, acute inflammation or the immune system mounting a sustained response because of either a persistent antigen (bacteria or virus), toxin, or the perception of a threat even when there is none, damaging the healthy cells and tissues. Chronic inflammation is also caused by poor lifestyle choices and ageing. If left untreated, it can lead to conditions like heart disease, stroke, Alzheimer’s, CKD, Diabetes etc1. This test measures the CRP and AA/EPA ratio as biomarkers of inflammation.

Analytes measured
C-Reactive Protein
AA/EPA Ratio(Arachidonic acid/ Eicosapentaenoi acid ratio)
Sampling type
Finger Prick blood sample on DBS card ; Home2Lab test Kit

3,095.00

Category:

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What’s measured

Arachidonic acid (AA) is a precursor to a number of pro-inflammatory mediators(eicosanoids). Eicosapentaenoic Acid (EPA) is a key anti-inflammatory long chain Omega-3 fatty acid. AA/EPA ratio is recommended as a marker of chronic inflammation. High levels of AA:EPA Ratio is related to several conditions such as hypertension, high cholesterol, cardiovascular disease and diabetes. The recommended optimal level of AA to EPA ratio is less than 3:1.

C-Reactive Protein or CRP is a protein produced primarily by the liver in response to inflammation. CRP is in general, considered a non-specific marker of inflammation and levels can be elevated in case of an infection or a host of other inflammatory diseases such as rheumatoid arthritis. You should consult a medical practitioner if your CRP levels are above 6mg/L.

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FAQ

What is acute and chronic inflammation? What is CRP? What is AA/EPA Ratio? What will my test results tell me?What are the various diseases linked to chronic inflammation?

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Resources

  1. 1. Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822-1832. doi:10.1038/s41591-019-0675-0 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147972/
  2. 2. Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018;9:754. Published 2018 Apr 13. doi:10.3389/fimmu.2018.00754. PMID: 29706967. https://pubmed.ncbi.nlm.nih.gov/29706967/
  3. 3. Shah SH, Newby LK. C-reactive protein: a novel marker of cardiovascular risk. Cardiol Rev. 2003;11(4):169-179. doi:10.1097/01.CRD.0000077906.74217.6E
  4. 4. Nelson JR, Raskin S. The eicosapentaenoic acid:arachidonic acid ratio and its clinical utility in cardiovascular disease. Postgrad Med. 2019;131(4):268-277. doi:10.1080/00325481.2019.1607414 PMID: 31063407. https://pubmed.ncbi.nlm.nih.gov/31063407/
  5. 5. Tutino V, De Nunzio V, Caruso MG, et al. Elevated AA/EPA Ratio Represents an Inflammatory Biomarker in Tumor Tissue of Metastatic Colorectal Cancer Patients. Int J Mol Sci. 2019;20(8):2050. Published 2019 Apr 25. doi:10.3390/ijms20082050 PMID: 31027294. https://pubmed.ncbi.nlm.nih.gov/31027294/
  6. 6. Wall R, Ross RP, Fitzgerald GF, Stanton C. Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutr Rev. 2010 May;68(5):280-9. doi: 10.1111/j.1753-4887.2010.00287. PMID: 20500789.https://pubmed.ncbi.nlm.nih.gov/20500789/
  7. 7. Simopoulos, AP., “Essential Fatty Acids in Health and Chronic Diseases”, Am J Clin Nutr 1999;70 (suppl):560S-9S.
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