Histamine Intolerance Test

Histamine Intolerance (HIT) Test

Home-To-Lab

Dried Blood Spot (DBS)

Diamine Oxidase

None
None

This home-to-lab test tests for deficiency of diamine-oxidase (DAO), which is the main enzyme responsible for breaking down histamine in the digestive tract. Produced mainly in the cells lining the small intestine, DAO plays a crucial role in regulating histamine levels. However, when DAO levels are insufficient or its activity is reduced, histamine can accumulate, leading to HIT symptoms, including digestive issues, skin problems, headaches, and more.

Key Indicators Reported: DAO

2,950.00

Category:

Only customers holding Indian debit or credit cards may place their order through this portal. International customers are requested to write to us at info@lipomic.com so that we may assist them in placing the order.

General FAQs

Home-to-lab testing allows individuals to collect samples comfortably at home. The main advantages of home sampling include convenience, privacy, and accessibility, as individuals can perform the tests at their own convenience.

Once the sample is collected, it is sent to our laboratory for analysis from anywhere in the world. You will be notified on your registered email once the results are ready, and can be downloaded from your registered account.

DBS testing is no more painful than a self-prick for a glucometer test. The kit contains one-time-use safety lancets which are used for pricking a finger and depositing a sample on a special filter paper card. The blood spot deposited on the filter paper card is allowed to dry, and hence the name dried blood spot.

Similarly, some tests may require saliva, urine or stool samples, which can also be collected on special filter paper cards. This makes the sample collection completely non-invasive.

Watching the instructional video and carefully reading the instruction manual before conducting the test should ensure a smooth experience. Should you encounter any difficulties, please do not hesitate to contact us for assistance.

Once we receive your sample, the average response time is 7-10 business days to receive the results.

Lipomic LifeSciences can provide evidence-based suggestions for lifestyle changes that you can make to positively impact your health. We can also connect you with leading medical experts who can guide and discuss potential next steps.


Test Specific FAQs

You can take this test any time of the day.

Histamine is a multifunctional molecule that plays a critical role in the body’s immune response to injury, infection, and allergens. While it is essential for mounting effective immune responses, dysregulated histamine signalling can contribute to inflammatory disorders, allergic diseases, and other immune-related condition. In recent years, histamine intolerance (HIT) has been recognised as a significant factor contributing to various digestive issues and overall wellness.

Diamine oxidase (DAO) is an enzyme, produced in the cells lining the small intestine, crucial for histamine metabolism. Understanding HIT, and its connection to DAO deficiency is essential for a healthy gut and digestive system.

DAO is the main enzyme responsible for breaking down histamine in the digestive tract. Produced mainly in the cells lining the small intestine, DAO plays a crucial role in regulating histamine levels and preventing HIT symptoms. However, when DAO levels are insufficient or its activity is reduced, histamine can accumulate, leading to intolerance symptoms.

Several factors can contribute to DAO deficiency or impaired function, including:

  • Genetic predisposition: Some individuals may have genetic variations that affect DAO production or activity, increasing their susceptibility to histamine intolerance.
  • Gastrointestinal disorders: Conditions such as leaky gut syndrome, small intestinal bacterial overgrowth (SIBO), or inflammatory bowel disease (IBD) can interfere with DAO production and function.
  • Nutrient deficiencies: DAO synthesis requires certain nutrients, including vitamin B6, vitamin C, and copper. Deficiencies in these nutrients can impair DAO production.
  • Medications: Some medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), prolonged use of antihistamines, histamine releasing drugs, antidepressants, and proton pump inhibitors, can inhibit DAO activity, making HIT symptoms worse.

Confusion between histamine intolerance and food allergies is common due to overlapping symptoms and triggers, but these are distinct conditions with different underlying mechanisms.

Food allergies involve an immune system response to specific proteins in certain foods. Allergic reactions have an immediate onset, ranging from minutes to a few hours after exposure to an allergen. Typical food allergy symptoms can range from mild to severe and may include skin reactions (such as hives, itching, or eczema), gastrointestinal symptoms (such as nausea, vomiting, or diarrhoea), respiratory symptoms (such as nasal congestion or wheezing), and in severe cases, anaphylaxis, a life-threatening allergic reaction.

HIT is not an immune system mediated response. HIT reactions often occur gradually and may be delayed, making them challenging to identify and diagnose.

Some of the common symptoms in HIT include:

  • Bloating‑most common symptom
  • Rashes, Hives, or Eczema
  • Headaches or migraines
  • Diarrhoea
  • Low blood pressure
  • Runny nose/congestion
  • Skin Flushing
  • Arrhythmia (irregular heartbeat)
  • Wheezing
  • Swelling of face/hands/lips
  • Heartburn
  • Itchy skin
  • PMS‑Premenstrual Headaches or painful cramps are most common

There is no cure for HIT or DAO deficiency. In case your result shows DAO deficiency (Red or Yellow region of the test report), avoiding or limiting certain foods is the best option for managing HIT.

Sample Report


Histamine Intolerance Test

Download Report

General FAQs

Home-to-lab testing allows individuals to collect samples comfortably at home. The main advantages of home sampling include convenience, privacy, and accessibility, as individuals can perform the tests at their own convenience.

Once the sample is collected, it is sent to our laboratory for analysis from anywhere in the world. You will be notified on your registered email once the results are ready, and can be downloaded from your registered account.

DBS testing is no more painful than a self-prick for a glucometer test. The kit contains one-time-use safety lancets which are used for pricking a finger and depositing a sample on a special filter paper card. The blood spot deposited on the filter paper card is allowed to dry, and hence the name dried blood spot.

Similarly, some tests may require saliva, urine or stool samples, which can also be collected on special filter paper cards. This makes the sample collection completely non-invasive.

Watching the instructional video and carefully reading the instruction manual before conducting the test should ensure a smooth experience. Should you encounter any difficulties, please do not hesitate to contact us for assistance.

Once we receive your sample, the average response time is 7-10 business days to receive the results.

Lipomic LifeSciences can provide evidence-based suggestions for lifestyle changes that you can make to positively impact your health. We can also connect you with leading medical experts who can guide and discuss potential next steps.


Test Specific FAQs

You can take this test any time of the day.

Histamine is a multifunctional molecule that plays a critical role in the body’s immune response to injury, infection, and allergens. While it is essential for mounting effective immune responses, dysregulated histamine signalling can contribute to inflammatory disorders, allergic diseases, and other immune-related condition. In recent years, histamine intolerance (HIT) has been recognised as a significant factor contributing to various digestive issues and overall wellness.

Diamine oxidase (DAO) is an enzyme, produced in the cells lining the small intestine, crucial for histamine metabolism. Understanding HIT, and its connection to DAO deficiency is essential for a healthy gut and digestive system.

DAO is the main enzyme responsible for breaking down histamine in the digestive tract. Produced mainly in the cells lining the small intestine, DAO plays a crucial role in regulating histamine levels and preventing HIT symptoms. However, when DAO levels are insufficient or its activity is reduced, histamine can accumulate, leading to intolerance symptoms.

Several factors can contribute to DAO deficiency or impaired function, including:

  • Genetic predisposition: Some individuals may have genetic variations that affect DAO production or activity, increasing their susceptibility to histamine intolerance.
  • Gastrointestinal disorders: Conditions such as leaky gut syndrome, small intestinal bacterial overgrowth (SIBO), or inflammatory bowel disease (IBD) can interfere with DAO production and function.
  • Nutrient deficiencies: DAO synthesis requires certain nutrients, including vitamin B6, vitamin C, and copper. Deficiencies in these nutrients can impair DAO production.
  • Medications: Some medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), prolonged use of antihistamines, histamine releasing drugs, antidepressants, and proton pump inhibitors, can inhibit DAO activity, making HIT symptoms worse.

Confusion between histamine intolerance and food allergies is common due to overlapping symptoms and triggers, but these are distinct conditions with different underlying mechanisms.

Food allergies involve an immune system response to specific proteins in certain foods. Allergic reactions have an immediate onset, ranging from minutes to a few hours after exposure to an allergen. Typical food allergy symptoms can range from mild to severe and may include skin reactions (such as hives, itching, or eczema), gastrointestinal symptoms (such as nausea, vomiting, or diarrhoea), respiratory symptoms (such as nasal congestion or wheezing), and in severe cases, anaphylaxis, a life-threatening allergic reaction.

HIT is not an immune system mediated response. HIT reactions often occur gradually and may be delayed, making them challenging to identify and diagnose.

Some of the common symptoms in HIT include:

  • Bloating- most common symptom
  • Rashes, Hives, or Eczema
  • Headaches or migraines
  • Diarrhoea
  • Low blood pressure
  • Runny nose/congestion
  • Skin Flushing
  • Arrhythmia (irregular heartbeat)
  • Wheezing
  • Watery eyes
  • Swelling of face/hands/lips
  • Heartburn
  • Itchy skin
  • PMS- Premenstrual Headaches or painful cramps are most common

There is no cure for HIT or DAO deficiency. In case your result shows DAO deficiency (Red or Yellow region of the test report), avoiding or limiting certain foods is the best option for managing HIT.

Sample Report


Histamine Intolerance Test

Download Report

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